SLE Disease Activity Score Calculator
1. Neuropsychiatric involvement
Neuropsychiatric features included in the SLICC classification criteria for SLE, including recent onset of seizure, psychosis, organic brain syndrome, acute confusional state, SLE retinal changes, peripheral neuropathy myelopathy, lupus headache, cerebrovascular accident and aseptic meningitis.
2. Systemic vasculitis
Systemic vasculitis involving large and medium-sized vessels or lupus enteritis.
3. Mucocutaneous vasculitis
Any mucocutaneous vasculitis or chilblain lupus.
4. Cardiac/Pulmonary involvement
Including shrinking lung, interstitial pneumonitis, diffuse alveolar hemorrhage, pulmonary hypertension, myocarditis, valvular dysfunction, Libman-Sacks endocarditis.
5. Serositis
Pleurisy, pericarditis or sterile peritonitis.
6. Proteinuria
Ratio mg/g or mg/24 h
Urinary protein-creatinine ratio (mg/g) or 24h urinary protein (mg/24h), above 500mg/g and 500mg/24h, respectively.
7. Arthritis
28 swollen joint count
Number of swollen joints in 28 joint count.
8. Myositis
Proximal muscle aching/weakness with elevated CPK/aldolase or electromyogram changes or a biopsy showing myositis.
9. Localized skin rash
Acute, subacute or chronic cutaneous lupus rashes included in the SLICC classification criteria, located only above the neck.
10. Generalized skin rash
Acute, subacute and chronic cutaneous lupus rashes included in the SLICC classification criteria, located below the neck (with or without rash above the neck).
11. Alopecia
Abnormal, patchy or diffuse loss of hair.
12. Mucosal ulcers
Oral or nasal ulcerations.
13. Hemolytic anemia
Anemia with positive direct Coombs test, increased serum LDH, and low serum haptoglobin.
14. Thrombocytopenia
Platelet count(G/L)
Platelet count (G/L), below 100 G/L platelets.
15. Leukopenia
Leukocyte count(G/L)
Leukocyte count (G/L), below 3 G/L white blood cells.
16. Hypocomplementemia
Decrease in C3 or C4 below the lower limit of normal for testing laboratory.
17. Increased anti-dsDNA
Increase in DNA binding above the upper limit of normal for testing laboratory.

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